The project focuses on deciphering a novel cancer vulnerability in Lymphoma. The gene of interest is involved in ubiquitin-like protein (UBL) signaling that seems to influence B-cell development. Molecular biology tasks include Western Blotting, cell culture, DNA-damage and replication assays, flow cytometry and image-based assays. Genetic modification of cancer cell lines utilizing CRISPR-Cas9 and shRNA-mediated knockdowns State-of-the-Art advanced techniques such as proximity-labeling, MassSpec proteomics, RNAseq Data analysis, figure generation and scientific presentations