Master Thesis in Epigenetic Cancer Research - Department of Medicine 2­­,­­ Hematology and Oncology

The project focuses on deciphering a novel cancer vulnerability in Lymphoma. The gene of interest is involved in ubiquitin and epigenetic signaling, which appear to influence B-cell development. Molecular biology tasks include Western Blotting, cell culture, DNA-damage and replication assays, flow cytometry and image-based assays. Genetic modification of cancer cell lines utilizing CRISPR-Cas9 and shRNA-mediated knockdowns State-of-the-Art advanced techniques such as proximity-labeling, MassSpec proteomics, RNAseq, and CHIP-seq Data analysis, figure generation and scientific presentations Bioinformatic analysis in R including exploratory data analysis, gene set enrichment analysis and figure generation utilizing ggplot and Bioconductor packages (optional) Code documentation with version control using GitHub (optional)